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ERK Inhibitor

ERK Inhibitor structure

CAS No.: 1049738-54-6

Chemical Name:: ERK Inhibitor

Synonyms: ERK Inhibitor - CAS 1049738-54-6 - Calbiochem;3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride;(5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride

CBNumber:: CB13136749

Molecular Formula:: C14H17ClN2O3S

Molecular Weight:: 328.81

MDL Number:: MFCD09038681

MOL File:: 1049738-54-6.mol

Last updated:2023-05-18 11:31:18

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ERK Inhibitor Properties

storage temp.	+2C to +8C
solubility	DMSO: 2 mg/ml
form	Light yellow solid

ERK Inhibitor price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	15944	ERK Inhibitor ≥95%	1049738-54-6	500μg	$32	2024-03-01	Buy
Cayman Chemical	15944	ERK Inhibitor ≥95%	1049738-54-6	1mg	$50	2024-03-01	Buy
Cayman Chemical	15944	ERK Inhibitor ≥95%	1049738-54-6	5mg	$117	2024-03-01	Buy
AK Scientific	9473CW	ErkInhibitor	1049738-54-6	5mg	$228	2021-12-16	Buy

Product number	Packaging	Price	Buy
15944	500μg	$32	Buy
15944	1mg	$50	Buy
15944	5mg	$117	Buy
9473CW	5mg	$228	Buy

ERK Inhibitor Chemical Properties,Uses,Production

Description

ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (K_D = 5 μM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2. Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC₅₀ = 15-20 μM), A549 lung carcinoma cells (IC₅₀ = 25 μM), Sum-159 estrogen receptor-negative breast cancer cells and HT1080 fibrosarcoma cells.

General Description

A cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC₅₀ ≤ 25 μM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a K_D of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.

Biochem/physiol Actions

Primary TargetERK

ERK Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

ERK Inhibitor Suppliers

Global( 23)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+8618829768577	gao490372054@gamil.com	China	1250	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+86-19164747840 +86-13119157289	13119157289@163.com	China	2971	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Shanghai Run-Biotech Co., Ltd.	021-57171705 13817537615	sales@run-biotech.com	China	2587	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58

Supplier	Advantage
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	58
Aladdin Scientific	58
Shanghai Run-Biotech Co., Ltd.	58
Sigma-Aldrich	80
BOC Sciences	65
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai Hongye Biotechnology Co. Ltd	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58

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(5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride ERK Inhibitor - CAS 1049738-54-6 - Calbiochem 3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride 1049738-54-6